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UDP-glucuronosyltransferase 1A1

Summary
UniProt ID
P22309
Gene Symbol
  • UGT1A1
  • GNT1
  • UGT1
Organism
Homo sapiens (human)
External Links
GlyConnect
GlyGen
P22309
PubChem
P22309
SwissLipids
The Human Metabolome Database
HMDBP00483
O-GlcNAcAtlas
P22309
Annotation
Keyword
  • Alternative splicing
  • Cytoplasm
  • Disease variant
  • Endoplasmic reticulum
  • Glycoprotein
  • Glycosyltransferase
  • Lipid metabolism
  • Reference proteome
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Annotation information from UniProt.
Sequence
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 4 entries
Position Description PubMed ID GlyTouCan ID Source
102 N-linked (GlcNAc...) asparagine
295 N-linked (GlcNAc...) asparagine
338
347 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 5 entries
Pathway Name Organism
APAP ADME Homo sapiens
Aspirin ADME Homo sapiens
Defective UGT1A1 causes hyperbilirubinemia Homo sapiens
Glucuronidation Homo sapiens
Heme degradation Homo sapiens
Disease
Displaying entries 41 - 50 of 257 in total
DO ID Disease Name Source
DOID:0110746 type 1 diabetes mellitus 7
DOID:0110747 type 1 diabetes mellitus 8
DOID:0110748 obsolete type 1 diabetes mellitus 9
DOID:0110749 type 1 diabetes mellitus 10
DOID:0110750 type 1 diabetes mellitus 11
DOID:0110751 type 1 diabetes mellitus 12
DOID:0110752 type 1 diabetes mellitus 13
DOID:0110753 type 1 diabetes mellitus 15
DOID:0110754 type 1 diabetes mellitus 17
DOID:0110755 type 1 diabetes mellitus 18
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024