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Alpha-2A adrenergic receptor

Summary

UniProt ID

P22909

Gene Symbol

Adra2a

Gene ID

25083

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P22909
Re-Glyco: P22909

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Methylation
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

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GO Term
cytoplasm
plasma membrane
neuronal cell body
receptor complex
postsynaptic membrane
glutamatergic synapse
presynapse
axon terminus
presynaptic active zone membrane
postsynaptic density membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 28 in total

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GO Term
presynaptic modulation of chemical synaptic transmission
positive regulation of cytokine production
G protein-coupled receptor signaling pathway
female pregnancy
platelet activation
positive regulation of cell migration
glucose homeostasis
negative regulation of insulin secretion
positive regulation of wound healing
fear response

Displaying **all 10** entries
GO Term
adrenergic receptor activity
alpha2-adrenergic receptor activity
alpha-2C adrenergic receptor binding
thioesterase binding
heterotrimeric G-protein binding
epinephrine binding
norepinephrine binding
protein kinase binding
protein homodimerization activity
protein heterodimerization activity

Annotation information from UniProt.

Sequence

MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
25	N-linked (GlcNAc...) asparagine			UniProt
29	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Adrenaline signalling through Alpha-2 adrenergic receptor	Rattus norvegicus
Adrenaline,noradrenaline inhibits insulin secretion	Rattus norvegicus
Adrenoceptors	Rattus norvegicus
G alpha (i) signalling events	Rattus norvegicus
G alpha (z) signalling events	Rattus norvegicus
Surfactant metabolism	Rattus norvegicus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:2030	anxiety disorder	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements