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Repository for lectin-assisted multimodality data
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MIRAGE
Neurotrophic factor BDNF precursor form
Summary
- UniProt ID
- P23363
- Gene Symbol
-
- Bdnf
- Gene ID
- 24225
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cleavage on pair of basic residues
- Disulfide bond
- Glycoprotein
- Growth factor
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| perinuclear region of cytoplasm |
| synaptic vesicle |
| mitochondrial crista |
| terminal bouton |
| perikaryon |
| hippocampal mossy fiber to CA3 synapse |
| glutamatergic synapse |
| neuronal dense core vesicle |
| extracellular region |
| extracellular space |
| GO Term |
|---|
| neurotrophin TRKB receptor binding |
| nerve growth factor receptor binding |
| growth factor activity |
Sequence
MTILFLTMVISYFGCMKAAPMKEANVHGQGNLAYPAVRTHGTLESVNGPRAGSRGLTTTSLADTFEHVIEELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 123 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NTRK2 signals through FRS2 and FRS3 | Rattus norvegicus |
| Activated NTRK2 signals through PLCG1 | Rattus norvegicus |
| NTRK2 activates RAC1 | Rattus norvegicus |
| PI3K/AKT Signaling | Rattus norvegicus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050741 | alcohol dependence | |
| DOID:10652 | Alzheimer's disease | |
| DOID:11446 | sciatic neuropathy | |
| DOID:1679 | cystitis | |
| DOID:1686 | glaucoma | |
| DOID:1824 | status epilepticus | |
| DOID:8466 | retinal degeneration | |
| DOID:9743 | diabetic neuropathy |
