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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Furin
Summary
- UniProt ID
- P23377
- Gene Symbol
-
- Furin
- Fur
- Pcsk3
- Organism
- Rattus norvegicus (Norway rat)
External Links
- PubChem
- P23377
Annotation
- Keyword
-
- Autocatalytic cleavage
- Calcium
- Cell membrane
- Cleavage on pair of basic residues
- Disulfide bond
- Endosome
- Glycoprotein
- Golgi apparatus
- Heparin-binding
- Metal-binding
- Phosphoprotein
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Transmembrane helix
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| extracellular region |
| plasma membrane |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| endosome membrane |
| Golgi cisterna |
| trans-Golgi network |
| cell surface |
| trans-Golgi network transport vesicle |
| GO Term |
|---|
| protease binding |
| heparin binding |
| peptidase activity |
| nerve growth factor binding |
| heparan sulfate binding |
| peptide binding |
| metal ion binding |
| endopeptidase activity |
| serine-type endopeptidase activity |
| serine-type endopeptidase inhibitor activity |
Sequence
MELRPWLLWVVAAAGALVLLAAEARGQKIFTNTWAVHISGGPAVADSVARKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQRVPQVKWLEQQVAKQRAKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLEVRKTVTACLGEPNHISRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASEGLSAPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQRCPPGFTPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSSRESRPQQPPPALRPEVEVEPRLRAGLASHLPEVLAGLSCLIIALIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of Matrix Metalloproteinases | Rattus norvegicus |
| Assembly of active LPL and LIPC lipase complexes | Rattus norvegicus |
| Collagen degradation | Rattus norvegicus |
| Elastic fibre formation | Rattus norvegicus |
| NGF processing | Rattus norvegicus |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | Rattus norvegicus |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Rattus norvegicus |
| Signaling by PDGF | Rattus norvegicus |
| TGF-beta receptor signaling activates SMADs | Rattus norvegicus |
