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Signaling by PDGF

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PDGF precursor dimers (AA, BB, A/B, CC, DD)PDGF precursor dimers (AA, BB, A/B, CC, DD)proPDGF-AA dimeractive PDGF-AA dimerPdgfaproPDGF-BB dimeractive PDGF-BB dimerPdgfbproPDGF-AB dimerPDGF A/B heterodimerNovel PDGF precursor dimers (CC, DD)Novel PDGF precursor dimers (CC, DD)Active PDGF dimers (CC, DD)Cleaved novel PDGF fragmentsPDGF A and B chains with retention motifPDGF A and B chains:ECM complexExtracellular matrix ligandsPDGFRA, PDGFRBPDGF:PDGF receptor dimerActive PDGF dimers (AA, AB, BB)PDGF beta receptor:PDGF chain B homodimerADPATPPhospho PDGF beta receptor: PDGF chain B homodimerPhospho PDGF alpha receptor:PDGF dimersPDGF alpha receptor: PDGF dimersPDGF alpha/beta:PDGF AB and BB dimersPhospho PDGF alpha-beta dimer:PDGF AB or BB dimersH2Op-PDGFRB homo and heterodimers dephosphorylated at Y1021Pip-PDGFRB homo and heterodimersPDGFR:type I PDGFR-binding TKIstype I PDGFR-binding tyrosine kinase inhibitorstype II PDGFR-binding tyrosine kinase inhibitorsPDGFR:type II PDGFR-binding TKIs
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025