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Insulin-like growth factor 1 receptor

Summary

UniProt ID

P24062

Gene Symbol

Igf1r

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P24062

Annotation

Keyword

ATP-binding
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Isopeptide bond
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **21 - 30** of 71 in total

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GO Term
positive regulation of MAPK cascade
phosphatidylinositol 3-kinase/protein kinase B signal transduction
estrous cycle
response to ethanol
protein autophosphorylation
insulin-like growth factor receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
prostate gland epithelium morphogenesis
cellular response to mechanical stimulus

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GO Term
T-tubule
plasma membrane
membrane
axon
neuronal cell body
intracellular membrane-bounded organelle
receptor complex
postsynapse
caveola
protein kinase complex

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GO Term
identical protein binding
insulin receptor substrate binding
protein-containing complex binding
G-protein alpha-subunit binding
protein tyrosine kinase activity
insulin-like growth factor receptor activity
insulin-like growth factor I binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin-like growth factor binding

Annotation information from UniProt.

Sequence

MKSGSGGGSPTSLWGLVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRDVLQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVENNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEMEPSFQEVSFYYSEENKPPEPEELEMELELEPENMESVPLDPSASSASLPLPERHSGHKAENGPGVLVLRASFDERQPYAHMNGGRANERALPLPQSSTC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	Source
51	N-linked (GlcNAc...) asparagine	UniProt
102	N-linked (GlcNAc...) asparagine	UniProt
135	N-linked (GlcNAc...) asparagine	UniProt
245	N-linked (GlcNAc...) asparagine	UniProt
314	N-linked (GlcNAc...) asparagine	UniProt
418	N-linked (GlcNAc...) asparagine	UniProt
439	N-linked (GlcNAc...) asparagine	UniProt
535	N-linked (GlcNAc...) asparagine	UniProt
608	N-linked (GlcNAc...) asparagine	UniProt
623	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Extra-nuclear estrogen signaling	Rattus norvegicus
IRS-related events triggered by IGF1R	Rattus norvegicus
SHC-related events triggered by IGF1R	Rattus norvegicus
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements