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MIRAGE
Beta-nerve growth factor
Summary
- UniProt ID
- P25427
- Gene Symbol
-
- Ngf
- Ngfb
- Gene ID
- 310738
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cleavage on pair of basic residues
- Disulfide bond
- Endosome
- Glycoprotein
- Growth factor
- Lipid-binding
- Metalloprotease inhibitor
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| endosome lumen |
| extracellular region |
| extracellular space |
| axon |
| dendrite |
| endoplasmic reticulum lumen |
| Golgi lumen |
| synaptic vesicle |
Sequence
MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSLDTALRRARSAPAEPIAARVTGQTRNITVDPKLFKKRRLRSPRVLFSTQPPPTSSDTLDLDFQAHGTISFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVLGEVNINNSVFKQYFFETKCRAPNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDDKQAAWRFIRIDTACVCVLSRKAARRG
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| ARMS-mediated activation | Rattus norvegicus |
| Axonal growth stimulation | Rattus norvegicus |
| Frs2-mediated activation | Rattus norvegicus |
| NADE modulates death signalling | Rattus norvegicus |
| NF-kB is activated and signals survival | Rattus norvegicus |
| NFG and proNGF binds to p75NTR | Rattus norvegicus |
| NGF processing | Rattus norvegicus |
| NRIF signals cell death from the nucleus | Rattus norvegicus |
| PI3K/AKT activation | Rattus norvegicus |
| Retrograde neurotrophin signalling | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070355 | overactive bladder syndrome | |
| DOID:0080809 | chronic asthma | |
| DOID:0081292 | traumatic brain injury | |
| DOID:12143 | neurogenic bladder | |
| DOID:13948 | bladder neck obstruction | |
| DOID:1679 | cystitis | |
| DOID:3525 | middle cerebral artery infarction | |
| DOID:8398 | osteoarthritis | |
| DOID:8947 | diabetic retinopathy | |
| DOID:90 | degenerative disc disease |
