degenerative disc disease

Summary
Synonym
  • cervical disc degenerative disease
  • intervertebral disc degeneration
  • lumbar disc degeneration
  • vertebral disc disease
Definition
A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.
Super Class
bone deterioration disease
Disease Ontology
DOID:90
Mondo Disease Ontology
UMLS
NCI Thesaurus
Related Genes
Displaying entries 1 - 10 of 18 in total
Gene ID Gene Symbol Description Source
176 ACAN aggrecan
1277 COL1A1 collagen type I alpha 1 chain
1280 COL2A1 collagen type II alpha 1 chain
1300 COL10A1 collagen type X alpha 1 chain
1398 CRK CRK proto-oncogene, adaptor protein
2353 FOS Fos proto-oncogene, AP-1 transcription factor subunit
2932 GSK3B glycogen synthase kinase 3 beta
4312 MMP1 matrix metallopeptidase 1
4314 MMP3 matrix metallopeptidase 3
4322 MMP13 matrix metallopeptidase 13
Displaying entries 1 - 10 of 15 in total
Gene ID Gene Symbol Description Source
11595 Acan aggrecan
12824 Col2a1 collagen, type II, alpha 1
12842 Col1a1 collagen, type I, alpha 1
14281 Fos FBJ osteosarcoma oncogene
17386 Mmp13 matrix metallopeptidase 13
18049 Ngf nerve growth factor
18053 Ngfr nerve growth factor receptor (TNFR superfamily, member 16)
18491 Pappa pregnancy-associated plasma protein A
21857 Timp1 tissue inhibitor of metalloproteinase 1
23794 Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5
Displaying all 9 entries
Gene ID Gene Symbol Description Source
24596 Ngfr nerve growth factor receptor
25412 Col2a1 collagen type II alpha 1 chain
29393 Col1a1 collagen type I alpha 1 chain
58968 Acan aggrecan
66015 Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
84027 Gsk3b glycogen synthase kinase 3 beta
116510 Timp1 TIMP metallopeptidase inhibitor 1
304135 Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
310738 Ngf nerve growth factor
Displaying all 2 entries
Gene ID Gene Symbol Description Source
31248 sgg shaggy
42850 Atg6 Autophagy-related 6
Displaying 1 entry
Gene ID Gene Symbol Description Source
58133 ngfb nerve growth factor b (beta polypeptide)
Displaying all 2 entries
Gene ID Gene Symbol Description Source Organism
394828 col2a1 collagen, type II, alpha 1 Xenopus tropicalis (tropical clawed frog)
100488158 adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 Xenopus tropicalis (tropical clawed frog)
Displaying all 3 entries
Gene ID Gene Symbol Description Source
177850 gon-1 A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein
178748 zmp-3 Matrix metalloproteinase-C
179197 cri-2 Putative metalloproteinase inhibitor tag-225
Displaying 1 entry
Gene ID Gene Symbol Description Source
850687 YLR001C uncharacterized protein

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Acknowledgements

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Last updated: December 9, 2024