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Progranulin

Summary

UniProt ID

P28799

Gene Symbol

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011645

GlyConnect

1290

GlyGen

P28799

PubChem

P28799

The O-GlcNAc Database

P28799

RaftProt

P28799

O-GlcNAcAtlas

P28799

Annotation

Keyword

3D-structure
Alternative splicing
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Neuronal ceroid lipofuscinosis
Reference proteome
Repeat
Secreted
Signal

Gene Ontology (GO)

Displaying entries **11 - 20** of 23 in total

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GO Term
regulation of inflammatory response
negative regulation of respiratory burst involved in inflammatory response
positive regulation of inflammatory response to wounding
positive regulation of defense response to bacterium
microglial cell activation involved in immune response
negative regulation of microglial cell activation
positive regulation of aspartic-type peptidase activity
positive regulation of lysosome organization
lysosome organization
negative regulation of neuron apoptotic process

Displaying entries **1 - 10** of 13 in total

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GO Term
azurophil granule lumen
lysosomal membrane
extracellular exosome
endosome
late endosome
endoplasmic reticulum
Golgi apparatus
trans-Golgi network
extracellular region
extracellular space

Displaying **all 4** entries
GO Term
RNA binding
cytokine activity
growth factor activity
protein-folding chaperone binding

Annotation information from UniProt.

Sequence

MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
118	N-linked (GlcNAc...) asparagine	20188224		UniProt GlyGen
178			G57321FI	GlyGen
180			G57321FI	GlyGen
182			G57321FI	GlyGen
236	N-linked (GlcNAc...) asparagine		G80920RR	GlycoProtDB UniProt GlyGen
265	N-linked (GlcNAc...) asparagine	19159218 20188224	G43769HG G83460ZZ G80920RR G62765YT G31852PQ G41247ZX G92050GC G41429FA	GlycoProtDB UniProt GlyGen
368	N-linked (GlcNAc...) asparagine	20188224		UniProt GlyGen
530	N-linked (GlcNAc...) asparagine	20188224	G79666IR G15664MX G27058EU G37509XX G72747WU G59626AS G08290VR G70101JE G80920RR G64409MC G62765YT G64527OM G47950XN G47644PP G95865ZB G23719VF G11314AS G57776ZU G92050GC G92275SC G14669DU G28681TP G31685JQ G63628AV	GlycoProtDB UniProt GlyGen GlyConnect
532			G14669DU G31685JQ G63628AV G49108TO	GlyGen The O-GlcNAc Database GlyConnect
537				GlyGen