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MIRAGE
Progranulin

Summary
UniProt ID
P28799
Gene Symbol
  • GRN
Gene ID
2896
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011645
GlyConnect
GlyGen
P28799
PubChem
P28799
The O-GlcNAc Database
P28799
RaftProt
P28799
O-GlcNAcAtlas
P28799
Re-Glyco
P28799
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cytokine
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Lysosome
  • Neuronal ceroid lipofuscinosis
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying entries 1 - 10 of 13 in total
GO Term
extracellular region
extracellular space
lysosome
plasma membrane
membrane
endosome
late endosome
endoplasmic reticulum
Golgi apparatus
trans-Golgi network
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 11 in total
Position Description PubMed ID GlyTouCan ID Source
118 N-linked (GlcNAc...) asparagine
178
180
182
236 N-linked (GlcNAc...) asparagine
265 N-linked (GlcNAc...) asparagine
272
368 N-linked (GlcNAc...) asparagine
530 N-linked (GlcNAc...) asparagine
532
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying 1 entry
Pathway Name Organism
Neutrophil degranulation Homo sapiens
Disease
Displaying all 7 entries
DO ID Disease Name Source
DOID:0050784 primary progressive multiple sclerosis
DOID:0060672 Grn-related frontotemporal lobar degeneration with Tdp43 inclusions
DOID:0110732 neuronal ceroid lipofuscinosis 11
DOID:10652 Alzheimer's disease
DOID:1307 dementia
DOID:332 amyotrophic lateral sclerosis
DOID:9255 frontotemporal dementia
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025