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RAC-alpha serine/threonine-protein kinase
Summary
- UniProt ID
- P31749
- Gene Symbol
-
- AKT1
- PKB
- RAC
- Gene ID
- 207
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Apoptosis
- Cell membrane
- Cytoplasm
- Developmental protein
- Disease variant
- Disulfide bond
- Glucose metabolism
- Glycogen biosynthesis
- Glycogen metabolism
- Glycoprotein
- Isopeptide bond
- Mitochondrion
- Neurogenesis
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Serine/threonine-protein kinase
- Sugar transport
- Translation regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| postsynapse |
| cytosol |
| mitochondrial intermembrane space |
| spindle |
| microtubule cytoskeleton |
| lamellipodium |
| ciliary basal body |
| nucleus |
| cytoplasm |
| plasma membrane |
| GO Term |
|---|
| protein serine/threonine kinase activity |
| calmodulin binding |
| ATP binding |
| enzyme binding |
| protein kinase binding |
| identical protein binding |
| protein homodimerization activity |
Sequence
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 126 | O-linked (GlcNAc) serine; alternate | |||
| 129 | O-linked (GlcNAc) serine; alternate | |||
| 305 | O-linked (GlcNAc) threonine | |||
| 308 |
|
|||
| 312 | O-linked (GlcNAc) threonine | |||
| 473 | O-linked (GlcNAc) serine; alternate |
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Regulation of PTEN stability and activity | Homo sapiens |
| Regulation of TP53 Activity through Acetylation | Homo sapiens |
| Regulation of TP53 Activity through Association with Co-factors | Homo sapiens |
| Regulation of TP53 Degradation | Homo sapiens |
| Regulation of localization of FOXO transcription factors | Homo sapiens |
| SARS-CoV-2 targets host intracellular signalling and regulatory pathways | Homo sapiens |
| TP53 Regulates Metabolic Genes | Homo sapiens |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | Homo sapiens |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | Homo sapiens |
| VEGFR2 mediated vascular permeability | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:0081002 | Cowden syndrome 6 | |
| DOID:10283 | prostate cancer | |
| DOID:1107 | esophageal carcinoma | |
| DOID:13482 | Proteus syndrome | |
| DOID:14330 | Parkinson's disease | |
| DOID:1612 | breast cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:219 | colon cancer | |
| DOID:2394 | ovarian cancer |
