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RAC-alpha serine/threonine-protein kinase

Summary

UniProt ID

P31750

Gene Symbol

Akt1
Akt
Rac

Organism

Mus musculus (house mouse)

External Links

GlyGen: P31750
PubChem: P31750
The Human Metabolome Database: HMDBP13418
The O-GlcNAc Database: P31750
O-GlcNAcAtlas: P31750

Annotation

Keyword

ATP-binding
Acetylation
Apoptosis
Cell membrane
Cytoplasm
Developmental protein
Disulfide bond
Glucose metabolism
Glycogen biosynthesis
Glycogen metabolism
Glycoprotein
Isopeptide bond
Mitochondrion
Neurogenesis
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Sugar transport
Translation regulation
Ubl conjugation

Gene Ontology (GO)

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GO Term
positive regulation of glucose import
regulation of aerobic respiration
cell migration involved in sprouting angiogenesis
sphingosine-1-phosphate receptor signaling pathway
epidermal growth factor receptor signaling pathway
apoptotic mitochondrial changes
protein ubiquitination
lipopolysaccharide-mediated signaling pathway
non-canonical NF-kappaB signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

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GO Term
nucleoplasm
spindle

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GO Term
GTPase activating protein binding
14-3-3 protein binding
potassium channel activator activity
protein serine kinase activity
protein serine/threonine kinase binding
protein kinase binding
protein serine/threonine kinase inhibitor activity
protein phosphatase 2A binding
nitric-oxide synthase regulator activity
protein homodimerization activity

Annotation information from UniProt.

Sequence

MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
126	O-linked (GlcNAc) serine; alternate			UniProt GlyGen
129	O-linked (GlcNAc) serine; alternate			UniProt GlyGen
305	O-linked (GlcNAc) threonine			UniProt GlyGen
308			G49108TO	GlyGen The O-GlcNAc Database
312	O-linked (GlcNAc) threonine			UniProt GlyGen
430			G49108TO	GlyGen The O-GlcNAc Database
473	O-linked (GlcNAc) serine; alternate	18570920		UniProt GlyGen
479			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **31 - 33** of 33 in total

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Pathway Name	Organism
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Mus musculus
VEGFR2 mediated vascular permeability	Mus musculus
eNOS activation	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements