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Beta-arrestin-2

Summary

UniProt ID

P32121

Gene Symbol

ARRB2
ARB2
ARR2

Organism

Homo sapiens (human)

External Links

GlyGen: P32121
PubChem: P32121
The Human Metabolome Database: HMDBP14520
The O-GlcNAc Database: P32121

Annotation

Keyword

Alternative splicing
Cell membrane
Coated pit
Cytoplasm
Cytoplasmic vesicle
Hydroxylation
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Signal transduction inhibitor
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 31 in total

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GO Term
negative regulation of protein phosphorylation
excitatory postsynaptic potential
positive regulation of synaptic transmission, dopaminergic
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of natural killer cell mediated cytotoxicity
cell chemotaxis
postsynaptic signal transduction
positive regulation of cardiac muscle cell differentiation

Displaying **all 10** entries
GO Term
postsynapse
glutamatergic synapse
cytosol
nucleoplasm
clathrin-coated pit
nucleus
cytoplasm
plasma membrane
endocytic vesicle
cytoplasmic vesicle

Displaying **all 8** entries
GO Term
G protein-coupled receptor binding
signaling receptor binding
enzyme binding
molecular adaptor activity
ubiquitin protein ligase binding
angiotensin receptor binding
D1 dopamine receptor binding
protein kinase B binding

Annotation information from UniProt.

Sequence

MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 15 in total

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Pathway Name	Organism
Activated NOTCH1 Transmits Signal to the Nucleus	Homo sapiens
Activation of SMO	Homo sapiens
Cargo recognition for clathrin-mediated endocytosis	Homo sapiens
Clathrin-mediated endocytosis	Homo sapiens
G alpha (s) signalling events	Homo sapiens
MAP2K and MAPK activation	Homo sapiens
Paradoxical activation of RAF signaling by kinase inactive BRAF	Homo sapiens
Signaling by BRAF and RAF1 fusions	Homo sapiens
Signaling by RAF1 mutants	Homo sapiens
Signaling by high-kinase activity BRAF mutants	Homo sapiens