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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alpha-L-iduronidase
Summary
- UniProt ID
- P35475
- Gene Symbol
-
- IDUA
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P35475
- PubChem
- P35475
- The Human Metabolome Database
- HMDBP01593
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Disease variant
- Disulfide bond
- Glycoprotein
- Glycosidase
- Lysosome
- Mucopolysaccharidosis
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular exosome |
| lysosomal lumen |
| GO Term |
|---|
| signaling receptor binding |
| L-iduronidase activity |
Sequence
MRPLRPRAALLALLASLLAAPPVAPAEAPHLVHVDAARALWPLRRFWRSTGFCPPLPHSQADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQLFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 110 | N-linked (GlcNAc...) asparagine | |||
| 190 | N-linked (GlcNAc...) asparagine |
|
||
| 336 | N-linked (GlcNAc...) asparagine |
|
||
| 372 | N-linked (GlcNAc...) asparagine | |||
| 415 | N-linked (GlcNAc...) asparagine | |||
| 451 | N-linked (GlcNAc...) asparagine | |||
|
|
|
G02815KT
G06110VR
G74724QE
G92275SC
G83460ZZ
G70101JE
G64527OM
G66676MI
G92406TI
G62765YT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CS/DS degradation | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
| MPS I - Hurler syndrome | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11949 | Creutzfeldt-Jakob disease | |
| DOID:11984 | hypertrophic cardiomyopathy | |
| DOID:12139 | dysthymic disorder | |
| DOID:1222 | cartilage disease | |
| DOID:1227 | neutropenia | |
| DOID:12603 | acute leukemia | |
| DOID:12721 | multiple epiphyseal dysplasia | |
| DOID:12798 | mucopolysaccharidosis | |
| DOID:12799 | mucopolysaccharidosis II | |
| DOID:12800 | mucopolysaccharidosis VI |
