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MIRAGE
TGF-beta receptor type-1
Summary
- UniProt ID
- P36897
- Gene Symbol
-
- ALK5
- SKR4
- TGFBR1
- Gene ID
- 7046
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P36897
- PubChem
- P36897
- The Human Metabolome Database
- HMDBP01288
- Re-Glyco
- P36897
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Aortic aneurysm
- Apoptosis
- Cell membrane
- Craniosynostosis
- Differentiation
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Growth regulation
- Isopeptide bond
- Magnesium
- Manganese
- Metal-binding
- Phosphoprotein
- Receptor
- Reference proteome
- Serine/threonine-protein kinase
- Signal
- Tight junction
- Transmembrane helix
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| ATP binding |
| ubiquitin protein ligase binding |
| SMAD binding |
| activin binding |
| transforming growth factor beta binding |
| transforming growth factor beta receptor activity, type III |
| I-SMAD binding |
| BMP receptor activity |
Sequence
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Glycosylation Sites
G80920RR
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Downregulation of TGF-beta receptor signaling | Homo sapiens |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | Homo sapiens |
| TGF-beta receptor signaling activates SMADs | Homo sapiens |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | Homo sapiens |
| TGFBR1 KD Mutants in Cancer | Homo sapiens |
| TGFBR1 LBD Mutants in Cancer | Homo sapiens |
| TGFBR2 Kinase Domain Mutants in Cancer | Homo sapiens |
| TGFBR3 regulates TGF-beta signaling | Homo sapiens |
| UCH proteinases | Homo sapiens |
| Ub-specific processing proteases | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070235 | Loeys-Dietz syndrome 1 | |
| DOID:11054 | urinary bladder cancer | |
| DOID:3498 | pancreatic ductal adenocarcinoma | |
| DOID:3883 | Lynch syndrome | |
| DOID:5585 | Ferguson-Smith tumor | |
| DOID:9256 | colorectal cancer |
