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MIRAGE
TGF-beta receptor type-2

Summary
UniProt ID
P37173
Gene Symbol
  • TGFBR2
Gene ID
7048
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011669
GlyConnect
GlyGen
P37173
PubChem
P37173
The Human Metabolome Database
HMDBP01237
RaftProt
P37173
Re-Glyco
P37173
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Alternative splicing
  • Aortic aneurysm
  • Apoptosis
  • Cell membrane
  • Craniosynostosis
  • Differentiation
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Growth regulation
  • Hereditary nonpolyposis colorectal cancer
  • Magnesium
  • Manganese
  • Metal-binding
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Secreted
  • Serine/threonine-protein kinase
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 10 entries
GO Term
extracellular region
extracellular space
plasma membrane
membrane
receptor complex
cytosol
external side of plasma membrane
caveola
membrane raft
transforming growth factor beta ligand-receptor complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 7 entries
Position Description PubMed ID GlyTouCan ID Source
31
39
70 N-linked (GlcNAc...) asparagine
94 N-linked (GlcNAc...) asparagine
154 N-linked (GlcNAc...) asparagine
266
564
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 10 entries
Pathway Name Organism
Downregulation of TGF-beta receptor signaling Homo sapiens
SMAD2/3 Phosphorylation Motif Mutants in Cancer Homo sapiens
TGF-beta receptor signaling activates SMADs Homo sapiens
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Homo sapiens
TGFBR1 KD Mutants in Cancer Homo sapiens
TGFBR1 LBD Mutants in Cancer Homo sapiens
TGFBR2 Kinase Domain Mutants in Cancer Homo sapiens
TGFBR2 MSI Frameshift Mutants in Cancer Homo sapiens
TGFBR3 regulates TGF-beta signaling Homo sapiens
UCH proteinases Homo sapiens
Disease
Displaying all 8 entries
DO ID Disease Name Source
DOID:0070234 Loeys-Dietz syndrome 2
DOID:0070273 hereditary nonpolyposis colorectal cancer type 6
DOID:0112182 mismatch repair cancer syndrome
DOID:14323 Marfan syndrome
DOID:1793 pancreatic cancer
DOID:219 colon cancer
DOID:3748 esophagus squamous cell carcinoma
DOID:3883 Lynch syndrome
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025