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Caspase-3

Summary

UniProt ID

P42574

Gene Symbol

CASP3
CPP32

Organism

Homo sapiens (human)

External Links

GlyGen: P42574
PubChem: P42574
The O-GlcNAc Database: P42574
RaftProt: P42574

Annotation

Keyword

3D-structure
Acetylation
Apoptosis
Cytoplasm
Direct protein sequencing
Phosphoprotein
Reference proteome
S-nitrosylation
Thiol protease
Zymogen

Gene Ontology (GO)

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GO Term
proteolysis
apoptotic process
heart development
sensory perception of sound
learning or memory
response to UV
response to wounding
protein processing
protein catabolic process
neuron differentiation

Displaying **all 6** entries
GO Term
cytosol
nucleoplasm
nucleus
cytoplasm
neuronal cell body
death-inducing signaling complex

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GO Term
aspartic-type endopeptidase activity
cysteine-type endopeptidase activity
cyclin-dependent protein serine/threonine kinase inhibitor activity
death receptor binding
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
cysteine-type endopeptidase activity involved in execution phase of apoptosis
enzyme activator activity
peptidase activity
protein-containing complex binding
phospholipase A2 activator activity

Annotation information from UniProt.

Sequence

MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Activation of caspases through apoptosome-mediated cleavage	Homo sapiens
Apoptosis induced DNA fragmentation	Homo sapiens
Apoptotic cleavage of cell adhesion proteins	Homo sapiens
Apoptotic cleavage of cellular proteins	Homo sapiens
Caspase-mediated cleavage of cytoskeletal proteins	Homo sapiens
Degradation of the extracellular matrix	Homo sapiens
Ligand-independent caspase activation via DCC	Homo sapiens
NADE modulates death signalling	Homo sapiens
Other interleukin signaling	Homo sapiens
Pyroptosis	Homo sapiens