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RAC-alpha serine/threonine-protein kinase
Summary
- UniProt ID
- P47196
- Gene Symbol
-
- Akt1
- Gene ID
- 24185
- Organism
- Rattus norvegicus (Norway rat)
External Links
- GlyGen
- P47196
- PubChem
- P47196
- The Human Metabolome Database
- HMDBP13421
- The O-GlcNAc Database
- P47196
- Re-Glyco
- P47196
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Apoptosis
- Cell membrane
- Cytoplasm
- Developmental protein
- Disulfide bond
- Glucose metabolism
- Glycogen biosynthesis
- Glycogen metabolism
- Glycoprotein
- Isopeptide bond
- Mitochondrion
- Neurogenesis
- Nucleus
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Sugar transport
- Translation regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| cytoplasm |
| mitochondrion |
| plasma membrane |
| cell-cell junction |
| membrane |
| dendrite |
| vesicle |
| protein-containing complex |
| nucleoplasm |
Sequence
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 126 | O-linked (GlcNAc) serine; alternate |
|
||
| 129 | O-linked (GlcNAc) serine; alternate |
|
||
| 305 | O-linked (GlcNAc) threonine |
|
||
| 312 | O-linked (GlcNAc) threonine |
|
||
| 473 | O-linked (GlcNAc) serine; alternate |
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AKT phosphorylates targets in the cytosol | Rattus norvegicus |
| AKT phosphorylates targets in the nucleus | Rattus norvegicus |
| AKT-mediated inactivation of FOXO1A | Rattus norvegicus |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | Rattus norvegicus |
| CD28 dependent PI3K/Akt signaling | Rattus norvegicus |
| CTLA4 inhibitory signaling | Rattus norvegicus |
| Cyclin A:Cdk2-associated events at S phase entry | Rattus norvegicus |
| Cyclin E associated events during G1/S transition | Rattus norvegicus |
| Deactivation of the beta-catenin transactivating complex | Rattus norvegicus |
| Downregulation of ERBB2:ERBB3 signaling | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110861 | autosomal recessive polycystic kidney disease | |
| DOID:10763 | hypertension | |
| DOID:1875 | impotence | |
| DOID:5844 | myocardial infarction | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:9976 | heroin dependence |
