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Iron-responsive element-binding protein 2

Summary

UniProt ID

P48200

Gene Symbol

IREB2

Gene ID

3658

Organism

Homo sapiens (human)

External Links

PubChem: P48200
The Human Metabolome Database: HMDBP01819
The O-GlcNAc Database: P48200
Re-Glyco: P48200

Annotation

Keyword

3D-structure
4Fe-4S
Alternative splicing
Cytoplasm
Disease variant
Neurodegeneration
RNA-binding
Reference proteome
Ubl conjugation

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
cytoplasm
mitochondrion
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 10** entries
GO Term
citrate metabolic process
protoporphyrinogen IX biosynthetic process
tricarboxylic acid cycle
intracellular iron ion homeostasis
mRNA stabilization
multicellular organismal-level iron ion homeostasis
post-embryonic development
osteoclast differentiation
erythrocyte homeostasis
intestinal absorption

Displaying **all 6** entries
GO Term
metal ion binding
iron-responsive element binding
mRNA regulatory element binding translation repressor activity
RNA binding
4 iron, 4 sulfur cluster binding
aconitate hydratase activity

Annotation information from UniProt.

Sequence

MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSICVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites