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Transcription factor SOX-2
Summary
- UniProt ID
- P48431
- Gene Symbol
-
- SOX2
- Gene ID
- 6657
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Activator
- Cytoplasm
- DNA-binding
- Developmental protein
- Disease variant
- Isopeptide bond
- Methylation
- Microphthalmia
- Nucleus
- Phosphoprotein
- Reference proteome
- Transcription regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nuclear speck |
| cytosol |
| chromatin |
| nucleus |
| cytoplasm |
| nucleoplasm |
| transcription regulator complex |
Sequence
MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 232 |
|
|
||
| 246 |
|
|||
| 249 |
|
|||
| 250 |
|
|||
| 251 |
|
|||
| 256 |
|
|||
| 257 |
|
|||
| 259 |
|
|||
| 309 |
|
G49108TO
G59324HL
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Deactivation of the beta-catenin transactivating complex | Homo sapiens |
| Formation of the anterior neural plate | Homo sapiens |
| Formation of the posterior neural plate | Homo sapiens |
| Interleukin-4 and Interleukin-13 signaling | Homo sapiens |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | Homo sapiens |
| POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | Homo sapiens |
| Primitive streak formation | Homo sapiens |
| Specification of the neural plate border | Homo sapiens |
| Transcriptional Regulation by MECP2 | Homo sapiens |
| Transcriptional and post-translational regulation of MITF-M expression and activity | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111801 | syndromic microphthalmia 3 | |
| DOID:10811 | nasal cavity cancer | |
| DOID:1612 | breast cancer |
