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Glutamate--cysteine ligase regulatory subunit

Summary

UniProt ID

P48507

Gene Symbol

GCLM
GLCLR

Organism

Homo sapiens (human)

External Links

GlyGen: P48507
PubChem: P48507
The Human Metabolome Database: HMDBP00513
The O-GlcNAc Database: P48507

Annotation

Keyword

Acetylation
Alternative splicing
Glutathione biosynthesis
Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 10** of 21 in total

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GO Term
glutamate metabolic process
response to oxidative stress
hepatic stellate cell activation
negative regulation of neuron apoptotic process
cellular response to glucose stimulus
response to nitrosative stress
regulation of mitochondrial depolarization
cellular response to leukemia inhibitory factor
response to nutrient
response to xenobiotic stimulus

Displaying **all 2** entries
GO Term
glutamate-cysteine ligase complex
cytosol

Displaying **all 4** entries
GO Term
enzyme regulator activity
protein-containing complex binding
glutamate-cysteine ligase activity
glutamate-cysteine ligase catalytic subunit binding

Annotation information from UniProt.

Sequence

MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Defective GCLC causes HAGGSD	Homo sapiens
Glutathione synthesis and recycling	Homo sapiens
NFE2L2 regulating anti-oxidant/detoxification enzymes	Homo sapiens