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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Summary

UniProt ID

P48736

Gene Symbol

PIK3CG

Gene ID

5294

Organism

Homo sapiens (human)

External Links

PubChem

P48736

SwissLipids

SLP:000000909

The Human Metabolome Database

HMDBP01392

The O-GlcNAc Database

P48736

Re-Glyco

P48736

Annotation

Keyword

3D-structure
ATP-binding
Angiogenesis
Cell membrane
Chemotaxis
Cytoplasm
Disease variant
Endocytosis
Immunity
Inflammatory response
Lipid metabolism
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
phosphatidylinositol 3-kinase complex, class IA
cytoplasm
plasma membrane
membrane
cytosol
phosphatidylinositol 3-kinase complex, class IB

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 40 in total

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GO Term
negative regulation of cardiac muscle contraction
platelet aggregation
angiogenesis
positive regulation of cytokine production
adaptive immune response
positive regulation of acute inflammatory response
respiratory burst involved in defense response
endocytosis
secretory granule localization
hepatocyte apoptotic process

Displaying **all 10** entries
GO Term
histone H2AS1 kinase activity
protein kinase activity
ATP binding
identical protein binding
ephrin receptor binding
protein serine kinase activity
1-phosphatidylinositol-3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
kinase activity

Annotation information from UniProt.

Sequence

MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
240			G49108TO	The O-GlcNAc Database
250			G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Homo sapiens
G beta:gamma signalling through PI3Kgamma	Homo sapiens
GPVI-mediated activation cascade	Homo sapiens
Synthesis of PIPs at the plasma membrane	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050211	swine influenza	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements