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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Summary
- UniProt ID
- P48736
- Gene Symbol
-
- PIK3CG
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P48736
- PubChem
- P48736
- SwissLipids
- The Human Metabolome Database
- HMDBP01392
- The O-GlcNAc Database
- P48736
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Angiogenesis
- Cell membrane
- Chemotaxis
- Cytoplasm
- Disease variant
- Endocytosis
- Immunity
- Inflammatory response
- Lipid metabolism
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Gene Ontology (GO)
| GO Term |
|---|
| respiratory burst involved in defense response |
| endocytosis |
| inflammatory response |
| immune response |
| G protein-coupled receptor signaling pathway |
| phosphorylation |
| T cell proliferation |
| T cell activation |
| mast cell degranulation |
| innate immune response |
| GO Term |
|---|
| cytoplasm |
| plasma membrane |
| membrane |
| cytosol |
| phosphatidylinositol 3-kinase complex, class IA |
| phosphatidylinositol 3-kinase complex, class IB |
Sequence
MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 240 |
|
|||
| 250 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | Homo sapiens |
| G beta:gamma signalling through PI3Kgamma | Homo sapiens |
| GPVI-mediated activation cascade | Homo sapiens |
| Synthesis of PIPs at the plasma membrane | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110759 | type 1 diabetes mellitus 22 | |
| DOID:0110760 | type 1 diabetes mellitus 23 | |
| DOID:0110761 | type 1 diabetes mellitus 24 | |
| DOID:0110844 | xeroderma pigmentosum group C | |
| DOID:0110858 | polycystic kidney disease 1 | |
| DOID:0110892 | inflammatory bowel disease 1 | |
| DOID:0110910 | leukocyte adhesion deficiency 1 | |
| DOID:0111005 | cone-rod dystrophy 2 | |
| DOID:0111029 | hemochromatosis type 1 | |
| DOID:0111135 | congenital generalized lipodystrophy type 1 |
