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Guidelines
MIRAGE
Matrix metalloproteinase-14
Summary
- UniProt ID
- P50281
- Gene Symbol
-
- MMP14
- Gene ID
- 4323
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P50281
- PubChem
- P50281
- The Human Metabolome Database
- HMDBP02912
- RaftProt
- P50281
- Re-Glyco
- P50281
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Cell membrane
- Cleavage on pair of basic residues
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Metal-binding
- Metalloprotease
- Osteoporosis
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular space |
| nucleus |
| plasma membrane |
| extracellular matrix |
| cytoplasmic vesicle |
| melanosome |
| intermediate filament cytoskeleton |
| Golgi lumen |
| cytosol |
| focal adhesion |
| GO Term |
|---|
| metalloaminopeptidase activity |
| serine-type endopeptidase activity |
| zinc ion binding |
| endopeptidase activity |
| metalloendopeptidase activity |
| integrin binding |
Sequence
MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
Glycosylation Sites
G57321FI
G29068FM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of Matrix Metalloproteinases | Homo sapiens |
| Collagen degradation | Homo sapiens |
| Degradation of the extracellular matrix | Homo sapiens |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | Homo sapiens |
| TGFBR3 PTM regulation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080696 | Winchester syndrome | |
| DOID:4914 | esophagus adenocarcinoma | |
| DOID:5844 | myocardial infarction |
