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Tyrosine-protein kinase JAK3

Summary

UniProt ID

P52333

Gene Symbol

JAK3

Organism

Homo sapiens (human)

External Links

GlyGen: P52333
PubChem: P52333
The Human Metabolome Database: HMDBP01358
The O-GlcNAc Database: P52333

Annotation

Keyword

3D-structure
ATP-binding
Adaptive immunity
Alternative splicing
Cytoplasm
Disease variant
Innate immunity
Membrane
Phosphoprotein
Reference proteome
Repeat
SCID
SH2 domain
Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 10** of 31 in total

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GO Term
adaptive immune response
negative regulation of dendritic cell cytokine production
protein phosphorylation
enzyme-linked receptor protein signaling pathway
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
cell differentiation
B cell differentiation
T cell homeostasis
innate immune response

Displaying **all 6** entries
GO Term
cytosol
endosome
extrinsic component of plasma membrane
extrinsic component of cytoplasmic side of plasma membrane
cytoskeleton
plasma membrane

Displaying **all 5** entries
GO Term
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
growth hormone receptor binding
ATP binding
protein phosphatase binding

Annotation information from UniProt.

Sequence

MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites