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Oxysterols receptor LXR-beta

Summary

UniProt ID

P55055

Gene Symbol

NR1H2
LXRB
NER
UNR

Organism

Homo sapiens (human)

External Links

GlyGen

P55055

PubChem

P55055

SwissLipids

SLP:000001551

The O-GlcNAc Database

P55055

Annotation

Keyword

3D-structure
Activator
Alternative splicing
DNA-binding
Isopeptide bond
Nucleus
Receptor
Reference proteome
Transcription regulation
Ubl conjugation
Zinc-finger

Gene Ontology (GO)

Displaying entries **21 - 28** of 28 in total

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GO Term
cell differentiation
hormone-mediated signaling pathway
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid transport
positive regulation of fatty acid biosynthetic process
negative regulation of proteolysis
positive regulation of protein metabolic process
negative regulation of pinocytosis

Displaying **all 6** entries
GO Term
chromatin
nucleus
cytoplasm
cytosol
nucleoplasm
RNA polymerase II transcription regulator complex

Displaying **all 10** entries
GO Term
DNA binding
ATPase binding
chromatin DNA binding
nuclear retinoid X receptor binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
nuclear receptor activity
RNA polymerase II cis-regulatory region sequence-specific DNA binding
zinc ion binding
apolipoprotein A-I receptor binding

Annotation information from UniProt.

Sequence

MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
LXRs regulate gene expression linked to cholesterol transport and efflux	Homo sapiens
LXRs regulate gene expression linked to lipogenesis	Homo sapiens
LXRs regulate gene expression linked to triglyceride lipolysis in adipose	Homo sapiens
LXRs regulate gene expression to control bile acid homeostasis	Homo sapiens
LXRs regulate gene expression to limit cholesterol uptake	Homo sapiens
Nuclear Receptor transcription pathway	Homo sapiens
PPARA activates gene expression	Homo sapiens
SUMOylation of intracellular receptors	Homo sapiens
VLDLR internalisation and degradation	Homo sapiens