LXRs regulate gene expression linked to cholesterol transport and efflux

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
KDM1A, KDM1B, KDM3A, KDM4AABCG1 gene:LXR:RXR:oxysterol:GPS2:KDMsABCG1 geneLXR:RXRLXR ligandGPS2ABCG1ABCA1gene:LXR:RXR:NCOR:GPS2:TBL1:HDAC3ABCA1gene:LXR:RXR:LXR ligands:NCOR:GPS2:TBL1:HDAC3ABCA1gene:LXR:RXR:LXR ligandsNCOR:GPS2:TBL1:HDAC3NCOA1NCOA1:LXR:RXR:LXR ligand:ABCA1 genep300EP300:NCOA1:LXR:RXR:LXR ligand:ABCA1 geneABCA1 geneABCA1 mRNAABCA1 mRNA:miR-26 RISCmiR-26 RISCmiR-33 RISCABCA1 mRNA:miR-33 RISCABCA1 mRNA:miR-144 RISCmiR-144 RISCABCA1NR1H2:RXRANR1H2:RXRA:ABCA1NR1H2,3:RXR:NR1H2,3 ligand:ABCG5 geneABCG5 geneABCG5ABCG8 geneLXR:RXR:LXR ligand:ABCG8 geneABCG8LXR:RXR:LXR ligand:CETP geneCETP geneCETPPLTP geneLXR:RXR:LXR ligand:PLTP genePLTPAPOE geneLXR:RXR:LXR ligand:APOE geneAPOELXR:RXR:LXR ligand:APOC1 geneAPOC1 geneAPOC1LXR:RXR:LXR ligand:APOC2 geneapoC-IIAPOC2APOC4 geneLXR:RXR:LXR ligand:APOC4 geneAPOC4LXR:RXR:LXR ligand:APOD geneAPOD geneAPODLXR:RXR:LXR ligand:EEPD1 geneEEPD1 geneEEPD1NR1H3 gene:LXR:RXR:LXR ligandsLXRA geneNR1H3 mRNANR1H3 mRNA:miR-613 RISCmiR-613 RISCNR1H3ARL7 geneLXR:RXR:LXR ligand:ARL4C geneARL4C mRNAARL7ARL4C mRNA:miR-26 RISC
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025