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Histone-lysine N-methyltransferase 2A
Summary
- UniProt ID
- P55200
- Gene Symbol
-
- All1
- Hrx
- Kmt2a
- Mll
- Mll1
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Acetylation
- Alternative splicing
- Biological rhythms
- Bromodomain
- Chromatin regulator
- DNA-binding
- Isopeptide bond
- Methylation
- Methyltransferase
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- S-adenosyl-L-methionine
- Transcription regulation
- Ubl conjugation
- Zinc-finger
- Gene Ontology (GO)
| GO Term |
|---|
| MLL1 complex |
| nucleus |
| cytosol |
| histone methyltransferase complex |
Sequence
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPQAGGGGPGAPPSPPAVAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKASPRKPRGRPRSGSDRNPAILSDPSVFSPLNKSETKSADKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDIAELTQGSKEDSLKKVKRTPSAMFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRIIPSCKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPMKIARLESTPNSRFSATSCGSSEKSSAASQHSSQMSSDSSRSSSPSIDTTSDSQASEEIQALPEERSNTPEVHTPLPISQSPENESNDRRSRRYSMSERSFGSRATKKLPTLQSAPQQQTSSSPPPPLLTPPPPLQPASGISDHTPWLMPPTIPLASPFLPASAAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDIHKRSPILRAPRFTPSEAHSRIFESVTLPSNRTSSGASSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSTSELSPLTPPSSVSSSLSIPVSPLAASALNPTFTFPSHSLTQSGESTEKNQRARKQTSALAEPFSSNSPALFPWFTPGSQTEKGRKKDTAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSDIQSSSALYPVGRVSKEKVAGEDVGTSSSAKKATGRKKSSSLDSGADVAPVTLGDTTAVKAKILIKKGRGNLEKNNLDLGPAAPSLEKERTPCLSAPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSVAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGICTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKASLQKQTKAVKKKEKKSKTTEKKESKESTAVKSPLEPAQKAAPPPREEPAPKKSSSEPPPRKPVEEKSEEGGAPAPAPAPEPKQVSAPASRKSSKQVSQPAAVVPPQPPSTAPQKKEAPKAVPSEPKKKQPPPPEPGPEQSKQKKVAPRPSIPVKQKPKDKEKPPPVSKQENAGTLNILNPLSNGISSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCESLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQASLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDEQQPLDLEGVKKRMDQGSYVSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSNNSGMLPNAVLPPSLDHNYAQWQEREESSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIDDNRQCALCLMYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIMECRPPVVEPDINSTVEHDDNRTIAHSPSSFIDASCKDSQSTAAILSPPSPDRPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPLRSKLRIMSPVRTGSAYSRSSVSSVPSLGTATDPEASAKASDRGGLLSSSANLGHSAPPSSSSQRTVGGSKTSHLDGSSPSEVKRCSASDLVPKGSLVKGEKNRTSSSKSTDGSAHSTAYPGIPKLTPQVHNATPGELNISKIGSFAEPSTVPFSSKDTVSYPQLHLRGQRSDRDQHMDPSQSVKPSPNEDGEIKTLKLPGMGHRPSILHEHIGSSSRDRRQKGKKSSKETCKEKHSSKSYLEPGQVTTGEEGNLKPEFADEVLTPGFLGQRPCNNVSSEKIGDKVLPLSGVPKGQSTQVEGSSKELQAPRKCSVKVTPLKMEGENQSKNTQKESGPGSPAHIESVCPAEPVSASRSPGAGPGVQPSPNNTLSQDPQSNNYQNLPEQDRNLMIPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSNSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATSRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVIKSAVGHKNEPKLDNCHSVSRVKAQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNAELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLTLGEGLGLDSNREKDIGLFEVFSQQLPATEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSEGDPALLSPGVDPAPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNSQDLTRNSGTPGLQVPVSPTVPVQNQKYVPSSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSPVSSTPSVMETNTSVLGPMGSGLTLTTGLNPSLPPSPSLFPPASKGLLSVPHHQHLHSFPAAAQSSFPPNISSPPSGLLIGVQPPPDPQLLGSEANQRTDLTTTVATPSSGLKKRPISRLHTRKNKKLAPSSAPSNIAPSDVVSNMTLINFTPSQLSNHPSLLDLGSLNPSSHRTVPNIIKRSKSGIMYFEQAPLLPPQSVGGTAATAAGSSTISQDTSHLTSGPVSALASGSSVLNVVSMQTTAAPTSSTSVPGHVTLANQRLLGTPDIGSISHLLIKASHQSLGIQDQPVALPPSSGMFPQLGTSQTPSAAAMTAASSICVLPSSQTAGMTAASPPGEAEEHYKLQRGNQLLAGKTGTLTSQRDRDPDSAPGTQPSNFTQTAEAPNGVRLEQNKTLPSAKPASSASPGSSPSSGQQSGSSSVPGPTKPKPKAKRIQLPLDKGSGKKHKVSHLRTSSEAHIPHRDTDPAPQPSVTRTPRANREQQDAAGVEQPSQKECGQPAGPVAALPEVQATQNPANEQENAEPKAMEEEESGFSSPLMLWLQQEQKRKESITERKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRQSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN
Glycosylation Sites
G31852PQ
G49108TO
G02815KT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Formation of WDR5-containing histone-modifying complexes | Mus musculus |
| PKMTs methylate histone lysines | Mus musculus |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Mus musculus |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | Mus musculus |
