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Caspase-7

Summary

UniProt ID

P55210

Gene Symbol

CASP7
MCH3

Gene ID

840

Organism

Homo sapiens (human)

External Links

GlyGen: P55210
PubChem: P55210
Re-Glyco: P55210

Annotation

Keyword

3D-structure
Acetylation
Allosteric enzyme
Alternative splicing
Apoptosis
Cytoplasm
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Secreted
Thiol protease
Zymogen

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
extracellular space
nucleus
cytoplasm
nucleoplasm
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 17 in total

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GO Term
fibroblast apoptotic process
cellular response to staurosporine
heart development
response to UV
neuron apoptotic process
cellular response to lipopolysaccharide
protein catabolic process
striated muscle cell differentiation
positive regulation of plasma membrane repair
lymphocyte apoptotic process

Displaying **all 7** entries
GO Term
cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity involved in execution phase of apoptosis
RNA binding
aspartic-type endopeptidase activity
cysteine-type endopeptidase activity
peptidase activity
cysteine-type peptidase activity

Annotation information from UniProt.

Sequence

MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
42			G80920RR	GlyGen
203			G96430BV G24528MX G51653BI G92406TI G46503DX G41840AI G73968GN G46910OC	GlyGen

Feature

Domains & sites

PTM

ProtVista

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Activation of caspases through apoptosome-mediated cleavage	Homo sapiens
Apoptotic cleavage of cellular proteins	Homo sapiens
Caspase-mediated cleavage of cytoskeletal proteins	Homo sapiens
SMAC (DIABLO) binds to IAPs	Homo sapiens
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	Homo sapiens
SMAC, XIAP-regulated apoptotic response	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources