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MIRAGE
Nicastrin

Summary
UniProt ID
P57716
Gene Symbol
  • Ncstn
Gene ID
59287
Organism
Mus musculus (house mouse)
GlycoProtDB
GPDB0003716
GlyConnect
GlyGen
P57716
PubChem
P57716
RaftProt
P57716
Re-Glyco
P57716
Annotation
Keyword
  • Cytoplasmic vesicle
  • Disulfide bond
  • Glycoprotein
  • Notch signaling pathway
  • Reference proteome
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying entries 1 - 10 of 16 in total
GO Term
membrane
cytoplasmic vesicle membrane
protein-containing complex
melanosome
Golgi membrane
early endosome
endoplasmic reticulum
endoplasmic reticulum membrane
Golgi apparatus
sarcolemma
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MATTRGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLKWVLTDGPNPPYMVLLEGKLFTRDVMEKLKGTTSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSVGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLSRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENIDSFVELGQVALRTSLDLWMHTDPMSQKNESVKNQVEDLLATLEKSGAGVPEVVLRRLAQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPEWQSPEEDLNFVTDTAKALANVATVLARALYELAGGTNFSSSIQADPQTVTRLLYGFLVRANNSWFQSILKHDLRSYLDDRPLQHYIAVSSPTNTTYVVQYALANLTGKATNLTREQCQDPSKVPNESKDLYEYSWVQGPWNSNRTERLPQCVRSTVRLARALSPAFELSQWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSTLVFSLIVTYCINAKADVLFVAPREPGAVSY
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 16 in total
Position Description PubMed ID GlyTouCan ID Source
44 N-linked (GlcNAc...) asparagine
54 N-linked (GlcNAc...) asparagine
128 N-linked (GlcNAc...) asparagine
186 N-linked (GlcNAc...) asparagine
203 N-linked (GlcNAc...) asparagine
263 N-linked (GlcNAc...) asparagine
386 N-linked (GlcNAc...) asparagine
434 N-linked (GlcNAc...) asparagine
463 N-linked (GlcNAc...) asparagine
505 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 8 entries
Pathway Name Organism
EPH-ephrin mediated repulsion of cells Mus musculus
NOTCH3 Activation and Transmission of Signal to the Nucleus Mus musculus
NRIF signals cell death from the nucleus Mus musculus
Neutrophil degranulation Mus musculus
Noncanonical activation of NOTCH3 Mus musculus
Nuclear signaling by ERBB4 Mus musculus
Regulated proteolysis of p75NTR Mus musculus
TGFBR3 PTM regulation Mus musculus
Disease
Displaying all 3 entries
DO ID Disease Name Source
DOID:11054 urinary bladder cancer
DOID:5419 schizophrenia
DOID:8552 chronic myeloid leukemia
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025