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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Proprotein convertase subtilisin/kexin type 9
Summary
- UniProt ID
- P59996
- Gene Symbol
-
- Pcsk9
- Narc1
- Organism
- Rattus norvegicus (Norway rat)
External Links
- PubChem
- P59996
Annotation
- Keyword
-
- Apoptosis
- Autocatalytic cleavage
- Calcium
- Cholesterol metabolism
- Cytoplasm
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Lysosome
- Phosphoprotein
- Reference proteome
- Secreted
- Serine protease
- Signal
- Sulfation
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| kidney development |
| liver development |
| apoptotic process |
| lysosomal transport |
| protein processing |
| neuron differentiation |
| cellular response to insulin stimulus |
| neurogenesis |
| lipoprotein metabolic process |
| regulation of neuron apoptotic process |
| GO Term |
|---|
| PCSK9-LDLR complex |
| PCSK9-AnxA2 complex |
| endoplasmic reticulum |
| early endosome |
| late endosome |
| extracellular region |
| extracellular space |
| cytoplasm |
| lysosome |
| Golgi apparatus |
Sequence
MGIRCSTWLRWPLSPQLLLLLLLCPTGSRAQDEDGDYEELMLALPSQEDSLVDEASHVATATFRRCSKEAWRLPGTYVVVLMEETQRLQVEQTAHRLQTWAARRGYVIKVLHVFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSLVFAQSIPWNLERIIPAWQQTEEDSSPDGSSQVEVYLLDTSIQSGHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNTACQRLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCYMSQSGTSQAAAHVAGIVAMMLNRDPALTLAELRQRLILFSTKDVINMAWFPEDQRVLTPNRVATLPPSTQETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDRIEAIGGQQVCKALNAFGGEGVYAVARCCLLPRVNCSIHNTPAARAGPQTPVHCHQKDHVLTGCSFHWEVENLRAQQQPLLRSRHQPGQCVGHQEASVHASCCHAPGLECKIKEHGIAGPAEQVTVACEAGWTLTGCNVLPGASLPLGAYSVDNVCVARIRDAGRADRTSEEATVAAAICCRSRPSAKASWVHQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 532 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| LDL clearance | Rattus norvegicus |
| Post-translational protein phosphorylation | Rattus norvegicus |
| Regulation of IGF Activity by IGFBP | Rattus norvegicus |
| VLDLR internalisation and degradation | Rattus norvegicus |
