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Proprotein convertase subtilisin/kexin type 9

Summary

UniProt ID

P59996

Gene Symbol

Pcsk9
Narc1

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P59996

Annotation

Keyword

Apoptosis
Autocatalytic cleavage
Calcium
Cholesterol metabolism
Cytoplasm
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Phosphoprotein
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Gene Ontology (GO)

Displaying entries **21 - 26** of 26 in total

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GO Term
negative regulation of low-density lipoprotein particle clearance
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
negative regulation of receptor-mediated endocytosis involved in cholesterol transport

Displaying entries **1 - 10** of 14 in total

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GO Term
extracellular region
extracellular space
cytoplasm
lysosome
Golgi apparatus
plasma membrane
PCSK9-LDLR complex
PCSK9-AnxA2 complex
endoplasmic reticulum
early endosome

Displaying **all 10** entries
GO Term
low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
very-low-density lipoprotein particle receptor binding
signaling receptor inhibitor activity
apolipoprotein binding
low-density lipoprotein particle receptor binding
sodium channel inhibitor activity
very-low-density lipoprotein particle binding
serine-type endopeptidase activity

Annotation information from UniProt.

Sequence

MGIRCSTWLRWPLSPQLLLLLLLCPTGSRAQDEDGDYEELMLALPSQEDSLVDEASHVATATFRRCSKEAWRLPGTYVVVLMEETQRLQVEQTAHRLQTWAARRGYVIKVLHVFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSLVFAQSIPWNLERIIPAWQQTEEDSSPDGSSQVEVYLLDTSIQSGHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNTACQRLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCYMSQSGTSQAAAHVAGIVAMMLNRDPALTLAELRQRLILFSTKDVINMAWFPEDQRVLTPNRVATLPPSTQETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDRIEAIGGQQVCKALNAFGGEGVYAVARCCLLPRVNCSIHNTPAARAGPQTPVHCHQKDHVLTGCSFHWEVENLRAQQQPLLRSRHQPGQCVGHQEASVHASCCHAPGLECKIKEHGIAGPAEQVTVACEAGWTLTGCNVLPGASLPLGAYSVDNVCVARIRDAGRADRTSEEATVAAAICCRSRPSAKASWVHQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
532	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
LDL clearance	Rattus norvegicus
Post-translational protein phosphorylation	Rattus norvegicus
Regulation of IGF Activity by IGFBP	Rattus norvegicus
VLDLR internalisation and degradation	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements