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Disintegrin and metalloproteinase domain-containing protein 8

Summary

UniProt ID

P78325

Gene Symbol

ADAM8
MS2

Gene ID

101

Organism

Homo sapiens (human)

External Links

GlyConnect

Disintegrin and metalloproteinase domain-containing protein 8

GlyGen

P78325

PubChem

P78325

Re-Glyco

P78325

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Signal
Transmembrane helix
Zinc

Gene Ontology (GO)

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GO Term
cytoplasm
plasma membrane
cell surface
podosome
phagolysosome
dense core granule membrane
tertiary granule
alpha9-beta1 integrin-ADAM8 complex
ficolin-1-rich granule membrane
specific granule membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 30 in total

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GO Term
positive regulation of epithelial to mesenchymal transition
extracellular matrix disassembly
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
angiogenesis
leukocyte migration involved in inflammatory response
positive regulation of acute inflammatory response
proteolysis
inflammatory response

Displaying **all 8** entries
GO Term
serine-type endopeptidase activity
calcium ion binding
zinc ion binding
tumor necrosis factor receptor superfamily binding
metalloendopeptidase activity
metallopeptidase activity
immunoglobulin receptor binding
cell adhesion molecule binding

Annotation information from UniProt.

Sequence

MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAGAPTAP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	GlyTouCan ID	Source
67	N-linked (GlcNAc...) asparagine		UniProt GlyGen
91	N-linked (GlcNAc...) asparagine	G80223IX G84452RH	UniProt GlyGen GlyConnect
436	N-linked (GlcNAc...) asparagine		UniProt GlyGen
612	N-linked (GlcNAc...) asparagine		UniProt GlyGen
822			GlyGen