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Disintegrin and metalloproteinase domain-containing protein 17

Summary

UniProt ID

P78536

Gene Symbol

ADAM17
CSVP
TACE

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011762

GlyConnect

1180

GlyGen

P78536

PubChem

P78536

The O-GlcNAc Database

P78536

O-GlcNAcAtlas

P78536

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Notch signaling pathway
Phosphoprotein
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Gene Ontology (GO)

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GO Term
neutrophil mediated immunity
germinal center formation
positive regulation of leukocyte chemotaxis
proteolysis
cell adhesion
positive regulation of cell population proliferation
protein processing
B cell differentiation
positive regulation of cell migration
cell motility

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GO Term
Golgi membrane
cytoplasm
plasma membrane
actin cytoskeleton
membrane
apical plasma membrane
cytosol
membrane raft
endoplasmic reticulum lumen
cell surface

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GO Term
peptidase activity
metal ion binding
SH3 domain binding
PDZ domain binding
endopeptidase activity
metalloendopeptidase activity
metallopeptidase activity
Notch binding
interleukin-6 receptor binding
integrin binding

Annotation information from UniProt.

Sequence

MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	GlyTouCan ID	Source
103	N-linked (GlcNAc...) asparagine	G29184RN G80920RR G62765YT G31852PQ G41247ZX	GlycoProtDB UniProt GlyGen
105		G49108TO	GlyGen The O-GlcNAc Database
108		G49108TO	GlyGen The O-GlcNAc Database
157	N-linked (GlcNAc...) asparagine	G80075MS G57776ZS G86880BF G87123QX G79666IR G45395BF G10819WX G70441OD G25079LO G70101JE G80920RR G90659AW G29299MO G62765YT	UniProt GlyGen GlyConnect
174	N-linked (GlcNAc...) asparagine	G80920RR	UniProt GlyGen
264	N-linked (GlcNAc...) asparagine	G27058EU G70101JE G80920RR G37399XV G82463GQ G14260UH G83633GK G62765YT G64527OM G28541PG G31852PQ G39188ZX G41247ZX G02815KT	UniProt GlyGen GlyConnect
265		G49108TO	GlyGen The O-GlcNAc Database
452	N-linked (GlcNAc...) asparagine	G40926MX G00912UN G60033FS G59626AS G20210JR G23294PN G70101JE G80920RR G82463GQ G62765YT G64527OM G10486CT G18647XP G02815KT	UniProt GlyGen GlyConnect
498	N-linked (GlcNAc...) asparagine	G86182NS	UniProt GlyGen
539	N-linked (GlcNAc...) asparagine	G99668VU G95133RI G86795LJ G27947YN G96577RX G81263BG G66163OV G40926MX G59536GA G08918WF G00912UN G70441OD G04657PL G27058EU G43769HG G20425TQ G60033FS G46902YN G44215PV G70619PT G06356OH G59626AS G20210JR G70101JE G80920RR G65184UU G90659AW G37399XV G62765YT G64527OM G72790NZ G10486CT G31852PQ	UniProt GlyGen GlyConnect