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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Mothers against decapentaplegic homolog 4
Summary
- UniProt ID
- P97471
- Gene Symbol
-
- Smad4
- Dpc4
- Madh4
- Organism
- Mus musculus (house mouse)
External Links
- GlyGen
- P97471
- PubChem
- P97471
- The Human Metabolome Database
- HMDBP14461
- The O-GlcNAc Database
- P97471
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Cytoplasm
- DNA-binding
- Isopeptide bond
- Metal-binding
- Nucleus
- Reference proteome
- Transcription regulation
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| negative regulation of canonical Wnt signaling pathway |
| ERK1 and ERK2 cascade |
| negative regulation of ERK1 and ERK2 cascade |
| positive regulation of miRNA transcription |
| GO Term |
|---|
| heteromeric SMAD protein complex |
Sequence
MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPAESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPVVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 3 |
|
|||
|
|
G02815KT
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | Mus musculus |
| FOXO-mediated transcription of cell cycle genes | Mus musculus |
| RUNX2 regulates bone development | Mus musculus |
| RUNX3 regulates CDKN1A transcription | Mus musculus |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Mus musculus |
| Signaling by Activin | Mus musculus |
| Signaling by BMP | Mus musculus |
| Signaling by NODAL | Mus musculus |
| TGF-beta receptor signaling activates SMADs | Mus musculus |
| Ub-specific processing proteases | Mus musculus |
