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Tyrosine-protein phosphatase non-receptor type substrate 1

Summary

UniProt ID

P97710

Gene Symbol

Sirpa
Bit
Mfr
Ptpns1
Shps1
Sirp

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P97710
PubChem: P97710

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Repeat
SH3-binding
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **21 - 30** of 36 in total

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GO Term
negative regulation of cytokine production involved in inflammatory response
cellular response to type II interferon
cellular response to lipopolysaccharide
negative regulation of JNK cascade
phagocytosis, recognition
phagocytosis, engulfment
cell-matrix adhesion
negative regulation of interferon-beta production
monocyte extravasation
cellular response to hydrogen peroxide

Displaying **all 2** entries
GO Term
plasma membrane
cell surface

Displaying **all 8** entries
GO Term
cell-cell adhesion mediator activity
protein antigen binding
SH3 domain binding
protein tyrosine kinase binding
protein phosphorylated amino acid binding
protein phosphatase binding
GTPase regulator activity
protein binding involved in heterotypic cell-cell adhesion

Annotation information from UniProt.

Sequence

MEPAGPAPGRLGPLLFCLLLSASCFCAGASGKELKVTQADKSVSVAAGDSATLNCTVSSLTPVGPIKWFKGEGQNRSPIYSFIGGEHFPRITNVSDATKRNNMDFSICISNVTPEDAGTYYCVKFQKGIVEPDTEIKSGGGTTLYVLAKPSSPEVSGPDSRGSPGQTVNFTCKSYGFSPRNITLKWLKDGKELSHLETTISSKSNVSYNISSTVSVKLSPEDIHSRVICEVAHVTLEGRPLNGTANFSNIIRVSPTLKITQQPLTPASQVNLTCQVQKFYPKALQLNWLENGNLSRTDKPEHFTDNRDGTYNYTSLFLVNSSAHREDVVFTCQVEHDSQPAITENHTVRAFAHSSSGGSMETIPDNNAYYNWNVFIGVGVACALLVVLLMAALYLLRIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPRVPEPNNHTEYASIETGKLPRPEDTLTYADLDMVHLNRAQPTPKPEPSFSEYASVQVQRK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 13 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
54	N-linked (GlcNAc...) asparagine			UniProt GlyGen
93	N-linked (GlcNAc...) asparagine	24090084	G60923RB G80920RR G67324HN G68318VE G83555HU G03574QJ G27622TD G62765YT G88725PI G10486CT G59937CP G31852PQ G72787SB G25987BV G39446WN G41247ZX G02815KT G92050GC	UniProt GlyGen
169	N-linked (GlcNAc...) asparagine	24090084	G09197ZW G80920RR G68318VE G02886BB G83555HU G27622TD G88725PI G10486CT G59937CP G92597CK G49955PK G72787SB G25987BV G39446WN G02815KT	UniProt GlyGen
181	N-linked (GlcNAc...) asparagine			UniProt GlyGen
205	N-linked (GlcNAc...) asparagine			UniProt GlyGen
209	N-linked (GlcNAc...) asparagine			UniProt GlyGen
242	N-linked (GlcNAc...) asparagine			UniProt GlyGen
246	N-linked (GlcNAc...) asparagine			UniProt GlyGen
271	N-linked (GlcNAc...) asparagine			UniProt GlyGen
293	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Cell surface interactions at the vascular wall	Rattus norvegicus
Neutrophil degranulation	Rattus norvegicus
Signal regulatory protein family interactions	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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External Links

Annotation

International Collaboration

Acknowledgements