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Forkhead box protein O4

Summary

UniProt ID

P98177

Gene Symbol

FOXO4
AFX
AFX1
MLLT7

Organism

Homo sapiens (human)

External Links

GlyGen: P98177
PubChem: P98177
The Human Metabolome Database: HMDBP08863
The O-GlcNAc Database: P98177

Annotation

Keyword

3D-structure
Acetylation
Activator
Alternative splicing
Cell cycle
Chromosomal rearrangement
Cytoplasm
DNA-binding
Developmental protein
Differentiation
Myogenesis
Nucleus
Pharmaceutical
Phosphoprotein
Proto-oncogene
Reference proteome
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

Displaying entries **11 - 15** of 15 in total

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GO Term
negative regulation of cell population proliferation
insulin receptor signaling pathway
positive regulation of smooth muscle cell migration
negative regulation of angiogenesis
response to nutrient levels

Displaying **all 6** entries
GO Term
nuclear speck
cytosol
nucleoplasm
chromatin
nucleus
cytoplasm

Displaying entries **1 - 10** of 13 in total

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GO Term
DNA-binding transcription factor binding
promoter-specific chromatin binding
identical protein binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
beta-catenin binding

Annotation information from UniProt.

Sequence

MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIAPPPVMASAPIPKALGTPVLTPPTEAASQDRMPQDLDLDMYMENLECDMDNIISDLMDEGEGLDFNFEPDP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
263			G02815KT	GlyGen
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
AKT phosphorylates targets in the nucleus	Homo sapiens
Cardiogenesis	Homo sapiens
Constitutive Signaling by AKT1 E17K in Cancer	Homo sapiens
FOXO-mediated transcription of cell cycle genes	Homo sapiens
FOXO-mediated transcription of cell death genes	Homo sapiens
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Homo sapiens
Regulation of FOXO transcriptional activity by acetylation	Homo sapiens
Regulation of localization of FOXO transcription factors	Homo sapiens
Ub-specific processing proteases	Homo sapiens