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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Epidermal growth factor receptor
Summary
- UniProt ID
- Q01279
- Gene Symbol
-
- Egfr
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0003854
- GlyConnect
- GlyGen
- Q01279
- PubChem
- Q01279
Annotation
- Keyword
-
- ATP-binding
- Cell membrane
- Developmental protein
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Hydroxylation
- Isopeptide bond
- Methylation
- Nucleus
- Palmitate
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| early endosome membrane |
| ruffle membrane |
| Golgi membrane |
| endosome |
| endoplasmic reticulum membrane |
| basal plasma membrane |
| cell surface |
| basolateral plasma membrane |
| apical plasma membrane |
| endocytic vesicle |
| GO Term |
|---|
| protein kinase binding |
| protein phosphatase binding |
| ubiquitin protein ligase binding |
| identical protein binding |
| protein-containing complex binding |
| epidermal growth factor binding |
| actin filament binding |
| protein tyrosine kinase activity |
Sequence
MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGSCRVKEDAFLQRYSSDPTGAVTEDNIDDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVGNPEYLNTAQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRVAPPSSEFIGA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 615 |
|
|
||
| 623 | N-linked (GlcNAc...) asparagine |
|
||
| 995 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cargo recognition for clathrin-mediated endocytosis | Mus musculus |
| Clathrin-mediated endocytosis | Mus musculus |
| Downregulation of ERBB2 signaling | Mus musculus |
| EGFR Transactivation by Gastrin | Mus musculus |
| EGFR downregulation | Mus musculus |
| EGFR interacts with phospholipase C-gamma | Mus musculus |
| ERBB2 Activates PTK6 Signaling | Mus musculus |
| ERBB2 Regulates Cell Motility | Mus musculus |
| Extra-nuclear estrogen signaling | Mus musculus |
| GAB1 signalosome | Mus musculus |
