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Fibroblast growth factor receptor 1

Summary

UniProt ID

Q04589

Gene Symbol

Fgfr1
Flg

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q04589

Annotation

Keyword

ATP-binding
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Heparin-binding
Immunoglobulin domain
Nucleus
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **51 - 60** of 86 in total

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GO Term
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
cellular response to nerve growth factor stimulus
diphosphate metabolic process
cementum mineralization
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
negative regulation of fibroblast growth factor production
positive regulation of mitotic cell cycle DNA replication
response to sodium phosphate
angiogenesis
ureteric bud development

Displaying **all 6** entries
GO Term
nucleus
plasma membrane
cytoplasmic vesicle
receptor complex
cytosol
perinuclear region of cytoplasm

Displaying entries **1 - 10** of 12 in total

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GO Term
protein tyrosine kinase activity
signaling receptor binding
heparin binding
protein-containing complex binding
SH2 domain binding
receptor-receptor interaction
cell adhesion molecule binding
identical protein binding
protein homodimerization activity
fibroblast growth factor receptor activity

Annotation information from UniProt.

Sequence

MWGWRGLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVRDSIPADSGLYACVTNSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYDQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWNAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQDSPSFPDTRSSTCSSGEDSVFSHEPFPEEPCLPRHPTQLANGGLNRR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	Source
77	N-linked (GlcNAc...) asparagine	UniProt
117	N-linked (GlcNAc...) asparagine	UniProt
227	N-linked (GlcNAc...) asparagine	UniProt
240	N-linked (GlcNAc...) asparagine	UniProt
264	N-linked (GlcNAc...) asparagine	UniProt
296	N-linked (GlcNAc...) asparagine	UniProt
317	N-linked (GlcNAc...) asparagine	UniProt
330	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Downstream signaling of activated FGFR1	Rattus norvegicus
FGFR1b ligand binding and activation	Rattus norvegicus
FGFR1c and Klotho ligand binding and activation	Rattus norvegicus
FGFR1c ligand binding and activation	Rattus norvegicus
FRS-mediated FGFR1 signaling	Rattus norvegicus
Negative regulation of FGFR1 signaling	Rattus norvegicus
PI-3K cascade:FGFR1	Rattus norvegicus
PI3K Cascade	Rattus norvegicus
PI3K/AKT Signaling	Rattus norvegicus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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International Collaboration

Acknowledgements