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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
3-ketodihydrosphingosine reductase
Summary
- UniProt ID
- Q06136
- Gene Symbol
-
- KDSR
- FVT1
- SDR35C1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q06136
- PubChem
- Q06136
- SwissLipids
- The Human Metabolome Database
- HMDBP03056
- The O-GlcNAc Database
- Q06136
Annotation
- Keyword
-
- Alternative splicing
- Chromosomal rearrangement
- Disease variant
- Endoplasmic reticulum
- NADP
- Nucleotide-binding
- Oxidoreductase
- Palmoplantar keratoderma
- Proto-oncogene
- Reference proteome
- Signal
- Sphingolipid metabolism
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| sphingolipid biosynthetic process |
| 3-keto-sphinganine metabolic process |
| GO Term |
|---|
| extracellular space |
| membrane |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| GO Term |
|---|
| 3-dehydrosphinganine reductase activity |
Sequence
MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDSIVRRCMMQREKSENADKTA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 212 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Sphingolipid de novo biosynthesis | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050428 | nonepidermolytic palmoplantar keratoderma | |
| DOID:0050467 | erythrokeratodermia variabilis | |
| DOID:0050486 | exanthem | |
| DOID:0050745 | diffuse large B-cell lymphoma | |
| DOID:0050873 | follicular lymphoma | |
| DOID:0060281 | photosensitive epilepsy | |
| DOID:0080250 | erythrokeratodermia variabilis et progressiva 4 | |
| DOID:0111195 | erythrokeratodermia variabilis et progressiva 1 | |
| DOID:10003 | sensorineural hearing loss |
