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MIRAGE
Rho guanine nucleotide exchange factor 2

Summary
UniProt ID
Q60875
Gene Symbol
  • Arhgef2
  • Kiaa0651
  • Lbcl1
  • Lfc
Gene ID
16800
Organism
Mus musculus (house mouse)
GlyGen
Q60875
RaftProt
Q60875
Re-Glyco
Q60875
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Coiled coil
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Developmental protein
  • Differentiation
  • Golgi apparatus
  • Guanine-nucleotide releasing factor
  • Innate immunity
  • Microtubule
  • Mitosis
  • Neurogenesis
  • Phosphoprotein
  • Proto-oncogene
  • Reference proteome
  • Tight junction
  • Zinc-finger
Gene Ontology (GO)
Displaying entries 1 - 10 of 14 in total
GO Term
cytoplasm
cytoskeleton
cytoplasmic vesicle
vesicle
protein-containing complex
neuronal cell body
Golgi apparatus
podosome
spindle
microtubule
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MSRIESLTRARIDRSKEQATKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLRNNTALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGSRRGLSSLSLAKSVSTTNIAGHFNDESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSWSLAVDSSFLQQHKKEVMKKQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEVVQGLFPCVDELSDIHTRFLNQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPVLINRILQNSHGVEEEYQDLASALGLVKELLSNVDQDVHELEKEARLQEIYNRMDPRAQTPVPGKGPFGRDELLRRKLIHEGCLLWKTATGRFKDVLLLLMTDVLVFLQEKDQKYIFTSLDKPSVVSLQNLIVRDIANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRLCPSREDFPLIETEDKAYLRRIKTKLQQKNQALVELLQKNVELFAEMVHFQALKAGFVGMPPPALPRGLFRLESFESLRGERLLKDALREVEGLKDLLLGPCVDLPMTSREPALPLDSDSGSCPGVTANGEARTFNGSIELCRADSDSSQKDRNGNQLRSPQEEVLQPLINLYGLLHGLQAVVVQQERLMEALFPEGPERWEKLSRANSRDGEAGRAAVASVTPEKQATELALLQRQHTLLQEELRRCQRLGEERATEAGSLEARLRESEQARALLEREAEEIRRQLAALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPSRGHDRLDLPVTVRSLHRPFDDREAQELGSPEDRLQDSSDPDTGSEEEVSSRLSPPHSPRDFTRMQDIPEETESRDGEPTASES
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 2 entries
Position Description PubMed ID GlyTouCan ID Source
72
101
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 4 entries
Pathway Name Organism
G alpha (12/13) signalling events Mus musculus
NRAGE signals death through JNK Mus musculus
RHOA GTPase cycle Mus musculus
RHOB GTPase cycle Mus musculus
Disease
Displaying 1 entry
DO ID Disease Name Source
DOID:0080312 neurodevelopmental disorder with midbrain and hindbrain malformations
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025