G alpha (12/13) signalling events

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ROCK1,ROCK2Activated ROCK:RhoA/B/C:GTPRhoA,B,C:GTPROCKiROCK1,ROCK2:ROCKiG-protein G12/G13 (inactive)Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive).Ligand:GPCR complexes that activate G12/13Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active).GTPGDPG-protein beta-gamma complexGPCRs that activate G12/13G-protein alpha (12/13):GTPLigands of GPCRs that activate G12/13G-protein alpha (13):GTPG13-activated p115-RhoGEFQ61210RHOA:GDPRhoA:GTPRhoA,B,C:GDPG-protein alpha (12/13):LARGQ8R4H2G-protein alpha (12/13):LARG:Plexin B1Plxnb1G-protein alpha (12/13):GDPBtkG alpha (12):BTKG-protein alpha (12):GTP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025