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Rho-associated protein kinase 1

Summary

UniProt ID

P70335

Gene Symbol

Rock1

Organism

Mus musculus (house mouse)

External Links

GlyGen: P70335
PubChem: P70335
The O-GlcNAc Database: P70335
RaftProt: P70335

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Apoptosis
Cell membrane
Cell projection
Coiled coil
Cytoskeleton
Golgi apparatus
Magnesium
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Zinc-finger

Gene Ontology (GO)

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GO Term
positive regulation of MAPK cascade
actomyosin structure organization
bleb assembly
regulation of actin cytoskeleton organization
regulation of actin filament-based process
regulation of keratinocyte differentiation
regulation of neuron differentiation
myoblast migration
regulation of microtubule cytoskeleton organization
protein localization to plasma membrane

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GO Term
Golgi membrane
cytoplasm
cytoskeleton
plasma membrane
Schaffer collateral - CA1 synapse
amyloid-beta complex
bleb
lamellipodium
ruffle
centriole

Displaying **all 7** entries
GO Term
aspartic-type endopeptidase inhibitor activity
ATP binding
small GTPase binding
protein serine/threonine kinase activity
metal ion binding
Rho-dependent protein serine/threonine kinase activity
protein serine kinase activity

Annotation information from UniProt.

Sequence

MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLPSANASENRSSSNVDKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNLKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEKRRNIENEVSTLKDQLEDLRKASQTSQLANEKLTQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQADKDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSIQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVETEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLALQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLRKIQELQSEKETLSTQLDLAETKAESEQLARGILEEQYFELTQESKKAASRNRQEITDKDHTVSRLEETNSVLTKDIEMLRKENEELNERMRTAEEEYKLKKEEEINNLKAAFEKNISTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDIEVEPVQQGEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	GlyTouCan ID	Source
410	G12261QD	GlyGen
580	G49108TO	GlyGen The O-GlcNAc Database
660	G70696MD	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Apoptotic cleavage of cellular proteins	Mus musculus
EPHB-mediated forward signaling	Mus musculus
G alpha (12/13) signalling events	Mus musculus
Neutrophil degranulation	Mus musculus
RHO GTPases Activate ROCKs	Mus musculus
RHOA GTPase cycle	Mus musculus
RHOB GTPase cycle	Mus musculus
RHOBTB1 GTPase cycle	Mus musculus
RHOC GTPase cycle	Mus musculus
RHOH GTPase cycle	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements