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Mothers against decapentaplegic homolog 2

Summary

UniProt ID

Q62432

Gene Symbol

Smad2
Madh2
Madr2

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q62432
PubChem: Q62432
The Human Metabolome Database: HMDBP14505

Annotation

Keyword

Acetylation
Alternative splicing
Cytoplasm
DNA-binding
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Ubl conjugation
Zinc

Gene Ontology (GO)

Displaying entries **1 - 10** of 52 in total

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GO Term
regulation of DNA-templated transcription
embryonic pattern specification
positive regulation of BMP signaling pathway
cell fate commitment
positive regulation of DNA-templated transcription
positive regulation of transcription by RNA polymerase II
in utero embryonic development
endoderm formation
mesoderm formation
gastrulation

Displaying **all 9** entries
GO Term
nucleoplasm
chromatin
nucleus
cytoplasm
protein-containing complex
transcription regulator complex
activin responsive factor complex
heteromeric SMAD protein complex
homomeric SMAD protein complex

Displaying entries **1 - 10** of 19 in total

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GO Term
chromatin binding
metal ion binding
tau protein binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA binding
double-stranded DNA binding
ubiquitin protein ligase binding
type I transforming growth factor beta receptor binding

Annotation information from UniProt.

Sequence

MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
322			G02815KT	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Downregulation of SMAD2/3:SMAD4 transcriptional activity	Mus musculus
Downregulation of TGF-beta receptor signaling	Mus musculus
FOXO-mediated transcription of cell cycle genes	Mus musculus
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	Mus musculus
Signaling by Activin	Mus musculus
Signaling by NODAL	Mus musculus
TGF-beta receptor signaling activates SMADs	Mus musculus
Ub-specific processing proteases	Mus musculus