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Runt-related transcription factor 1
Summary
- UniProt ID
- Q63046
- Gene Symbol
-
- Aml1
- Cbfa2
- Runx1
- Gene ID
- 50662
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Acetylation
- Activator
- DNA-binding
- Methylation
- Nucleus
- Phosphoprotein
- Reference proteome
- Repressor
- Transcription regulation
- Gene Ontology (GO)
| GO Term |
|---|
| core-binding factor complex |
| chromatin |
| basement membrane |
| nucleus |
Sequence
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQYLGSITSSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDPRQFPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSTSRYHTYLPPPYPGSSQAQAGPFQTGSPSYHLYYGTSAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDVVETEGSHSNSPTNMPPARLEEAVWRPY
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 219 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Estrogen-dependent gene expression | Rattus norvegicus |
| Organic cation transport | Rattus norvegicus |
| RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | Rattus norvegicus |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | Rattus norvegicus |
| RUNX1 regulates estrogen receptor mediated transcription | Rattus norvegicus |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Rattus norvegicus |
| RUNX1 regulates transcription of genes involved in BCR signaling | Rattus norvegicus |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | Rattus norvegicus |
| RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | Rattus norvegicus |
| RUNX1 regulates transcription of genes involved in interleukin signaling | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3525 | middle cerebral artery infarction |
