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Stimulator of interferon genes protein

Summary

UniProt ID

Q86WV6

Gene Symbol

STING1
ERIS
MITA
STING
TMEM173

Organism

Homo sapiens (human)

External Links

PubChem: Q86WV6
The Human Metabolome Database: HMDBP12695
The O-GlcNAc Database: Q86WV6
RaftProt: Q86WV6

Annotation

Keyword

3D-structure
Autophagy
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Disease variant
Endoplasmic reticulum
Golgi apparatus
Host-virus interaction
Innate immunity
Ion channel
Isopeptide bond
Mitochondrion outer membrane
Nucleotide-binding
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 23 in total

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GO Term
positive regulation of macroautophagy
positive regulation of type I interferon production
positive regulation of interferon-beta production
cellular response to interferon-beta
protein complex oligomerization
reticulophagy
protein localization to endoplasmic reticulum
cellular response to organic cyclic compound
antiviral innate immune response
cGAS/STING signaling pathway

Displaying entries **1 - 10** of 16 in total

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GO Term
endoplasmic reticulum-Golgi intermediate compartment membrane
autophagosome membrane
STING complex
Golgi membrane
nucleoplasm
endosome
endoplasmic reticulum membrane
cytosol
perinuclear region of cytoplasm
plasma membrane

Displaying **all 9** entries
GO Term
protein kinase binding
ubiquitin protein ligase binding
cyclic-di-GMP binding
signaling adaptor activity
identical protein binding
protein homodimerization activity
2',3'-cyclic GMP-AMP binding
RNA polymerase II-specific DNA-binding transcription factor binding
proton channel activity

Annotation information from UniProt.

Sequence

MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
229			G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
IRF3-mediated induction of type I IFN	Homo sapiens
Neutrophil degranulation	Homo sapiens
Regulation of innate immune responses to cytosolic DNA	Homo sapiens
SARS-CoV-1 activates/modulates innate immune responses	Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Homo sapiens
STAT6-mediated induction of chemokines	Homo sapiens
STING mediated induction of host immune responses	Homo sapiens