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Fibroblast growth factor receptor substrate 2

Summary

UniProt ID

Q8C180

Gene Symbol

Frs2
Frs2a

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q8C180
PubChem: Q8C180
O-GlcNAcAtlas: Q8C180

Annotation

Keyword

Direct protein sequencing
Membrane
Myristate
Phosphoprotein
Reference proteome
Ubl conjugation

Gene Ontology (GO)

Displaying entries **11 - 19** of 19 in total

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GO Term
positive regulation of vascular associated smooth muscle cell proliferation
negative regulation of cardiac muscle cell differentiation
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
lens placode formation involved in camera-type eye formation
organ induction
fibroblast growth factor receptor signaling pathway
positive regulation of MAPK cascade
cellular response to fibroblast growth factor stimulus
regulation of ERK1 and ERK2 cascade

Displaying **all 5** entries
GO Term
cytoplasm
plasma membrane
cell-cell junction
cytosol
adherens junction

Displaying **all 3** entries
GO Term
fibroblast growth factor receptor binding
transmembrane receptor protein tyrosine kinase adaptor activity
neurotrophin TRKA receptor binding

Annotation information from UniProt.

Sequence

MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGVMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERSSHQTELEVPRTPRTPTTPGLGAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRASVHVPPEARVSNAESNTPKEEPSNPEDRDPQVLLKPEGVRFVLGPTPVQKQLMEKEKLEQLGKDPVSGSGAGNTEWDTGYDSDERRDVPPVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRPALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIDYSKRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	GlyTouCan ID	Source
326	G49108TO	GlyGen
328	G49108TO	GlyGen
329	G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 21 in total

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Pathway Name	Organism
Activated NTRK2 signals through FRS2 and FRS3	Mus musculus
FRS-mediated FGFR1 signaling	Mus musculus
FRS-mediated FGFR2 signaling	Mus musculus
FRS-mediated FGFR3 signaling	Mus musculus
FRS-mediated FGFR4 signaling	Mus musculus
Frs2-mediated activation	Mus musculus
Negative regulation of FGFR1 signaling	Mus musculus
Negative regulation of FGFR2 signaling	Mus musculus
Negative regulation of FGFR3 signaling	Mus musculus
Negative regulation of FGFR4 signaling	Mus musculus