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MIRAGE
Frs2-mediated activation

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Frs2Active TrkA receptor:FRS2 complexActivated TrkA receptor complexADPATPActive TrkA receptor:p-FRS2 complexQ3UHC1Active TrkA receptor:p-FRS2:CRKL:RAPGEF1Active TrkA receptor:p-FRS2:CRKL complexRAP1:GTP:B-Raf complexRAP1:GTP:activated BRAF dimerRAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complexMAP2K homo/heterodimersMAPKsRAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complexRAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complexp-T,Y MAPKsp-2S MAP2K homo/heterodimersp-ERK dimerp-T,Y MAPK dimers
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025