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Serine/threonine-protein kinase B-raf
Summary
- UniProt ID
- P28028
- Gene Symbol
-
- B-raf
- Braf
- Gene ID
- 109880
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Allosteric enzyme
- Alternative splicing
- Cell membrane
- Chromosomal rearrangement
- Cytoplasm
- Isopeptide bond
- Metal-binding
- Methylation
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Serine/threonine-protein kinase
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| glutamatergic synapse |
| nucleus |
| cytoplasm |
| mitochondrion |
| plasma membrane |
| neuron projection |
| cell body |
| presynapse |
| postsynapse |
| cytosol |
Sequence
MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLVFQTPTDASRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSGSSSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGGFPVH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 476 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Frs2-mediated activation | Mus musculus |
| MAP2K and MAPK activation | Mus musculus |
| Negative feedback regulation of MAPK pathway | Mus musculus |
| Negative regulation of MAPK pathway | Mus musculus |
| RAF activation | Mus musculus |
| Spry regulation of FGF signaling | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060233 | cardiofaciocutaneous syndrome | |
| DOID:1909 | melanoma | |
| DOID:2571 | Langerhans-cell histiocytosis | |
| DOID:3969 | papillary thyroid carcinoma |
