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MIRAGE
MAP2K and MAPK activation

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
MAP2K homo/heterodimersactivated RAF:scaffold:MAP2K:MAPK complexMAPKsp21 RAS:GTP:activated RAF homo/heterodimer complexesRAF/MAPK scaffoldsdual mechanism MAP2K1/2 inhibitorsactivated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitorsactivated RAF:scaffold:p-2S MAP2K:MAPK complexADPATPsingle mechanism MAP2K1/2 inhibitorsactivated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitorsactivated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitorsdual mechanism MAPK inhibitorsactivated RAF:scaffold:p-2S MAP2K:p-2T MAPK complexp21RAS:GTP:activated RAF homo/heterodimersp-2S MAP2K homo/heterodimersp-T,Y MAPKsactivated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitorssingle mechanism MAPK inhibitorsWDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complexactivated RAF homo/heterodimerWDR83:LAMTOR2:LAMTOR3WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complexIl17rdIL17RD:p-2S MAP2Ks:MAPKsIL17RD:p-2S MAP2Ks:p-T,Y MAPKs
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025